ReviewBiomolecules2025
Hyaluronic Acid in Topical Applications: The Various Forms and Biological Effects of a Hero Molecule in the Cosmetics Industry.
Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A serum and cream moisturization regimen outperforms separate use in sustaining hydration, reducing TEWL, and balancing surface lipids over an 8-h study.International journal of cosmetic science · 2026Trial
- Molecular Targets in Modern Cosmetic Science.Molecules (Basel, Switzerland) · 2026Review
- Hydrogel facial mask for sensitive skin: A pilot study of long-term effects on hydration, barrier function and mechanical properties.International journal of cosmetic science · 2026Article
- Development and Characterization of Honey- and Essential Oil-Based Structured Systems for Skin Applications.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Article
- Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing.Pharmaceutics · 2026Review
- Hyaluronic Acid-Phospholipid Hybrid Nanocarriers (Hyalutocosomes) for Enhanced Dermal Delivery of Vitamin E and Photoprotection.Scientific reports · 2026Article
- Nitric oxide-releasing hyaluronic acid as an antibacterial and immunomodulatory acne therapeutic.RSC advances · 2026Article
- Dermofunctional Vehicle Downregulates LL-37 and MMPs and Upregulates IGFBP-3.Current issues in molecular biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyaluronan, or hyaluronic acid (HA), is a glycosaminoglycan with structural and signaling functions playing key roles in human skin homeostasis. It ensures hydration and biomechanical properties of this tissue as well as regulates cell adhesion, migration, proliferation, and inflammation. Its biocompatibility, viscoelastic properties, biological functions, and large-scale sustainable bioproduction made this polysaccharide a hero molecule of the cosmetic industry.
methodsA literature search was conducted to discuss the skin and hair benefits of the external use of HA and its derivatives. Four main questions were addressed: What are the different forms of HA in cosmetic formulations? What about their safety? Does HA penetrate human skin and hair? What are the benefits and mode of actions of HA, and its derivatives, in the fields of cosmetic and dermatology?
resultsThe analysis revealed HA below 100 kDa to penetrate skin, and lower molecular weight being able to reach the dermis. The safety of HA-containing formulations has been evaluated in several clinical trials and is supported by independent reports of commercial ingredients. We described HA molecules having beneficial effects on skin and hair, as well as their mode of action.
conclusionsThis review provides comprehensive information on the nature and efficacy of topical HA, and its derivatives, in cosmetic applications, with an emphasis on hair care. New areas of research were highlighted as the vectorization of high-molecular-weight HA.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.