ArticleAntibiotics (Basel, Switzerland)2025
Accessing Citrus and Soybean Flavonoids as Potential Efflux Pump Inhibitors in Drug-Resistant
Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chrysin mitigates ciprofloxacin-induced nephrotoxicity: associations with notch/HES1 signaling, inflammation, and a ferroptosis-related molecular signature.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
objectivesDrug efflux pumps represent a significant challenge that contributes to the development of antibiotic resistance in bacteria. This research aimed to evaluate the flavonoids apigenin, chrysin, glycitein, and hesperetin for their potential to inhibit efflux pumps in drug-resistant
methodThe antibacterial activity of the flavonoids was assessed using minimum inhibitory concentration (MIC) and modulation assays. Dye accumulation and efflux assays were performed to evaluate effects on efflux pump function, while membrane permeability and biofilm formation assays were also conducted. Molecular docking was used to examine interactions between the flavonoids and the AcrB efflux transporter.
resultsAlthough the flavonoids showed limited intrinsic antibacterial activity, they enhanced the effectiveness of erythromycin, ciprofloxacin, and clarithromycin against drug-resistant
conclusionsThe results suggest that apigenin and chrysin have promising efflux-pump inhibitory potential in drug-resistant
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