Evidence map›Paper›PMID 41465183›Full record

ArticleGenes2025

Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4.

Malcolm Anthony, Yixin Xie, Jahn N O'Neil, Shaolei Teng

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Malcolm AnthonyDepartment of Biology, Howard University, Washington, DC 20059, USA.
Yixin XieCollege of Computer Science and Software Engineering, Kennesaw State University, Marietta, GA 30060, USA.ORCID 0000-0002-4436-3474
Jahn N O'NeilDepartment of Physiology & Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.
Shaolei TengDepartment of Biology, Howard University, Washington, DC 20059, USA.ORCID 0000-0001-8326-9889

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI Emily M Cramer · 2019 to 2026
$37.7M
Platform for Analyzing the Mutations associated with Schizophrenia (PAMS)R16GM159167 · NIGMS · HOWARD UNIVERSITY · PI Shaolei Teng · 2025 to 2026
$274k
NIGMS NIH HHS R16 GM159167NIH HHS 1R16GM159167-01NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseApolipoprotein E3Apolipoprotein E4Amino Acid SequenceHumansMolecular Dynamics SimulationMutation, MissenseProtein StabilitySequence AlignmentApolipoprotein E3Apolipoprotein E4Alzheimer’s diseaseAPOEcomputational saturation mutagenesismolecular dynamics simulationprotein stability

Identifiers

PMID41465183
PMCPMC12732417

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.