Evidence map›Paper›PMID 41465193›Full record

Observational studyGenes2025

The

Jamila Alessandra Perini, Igor Stefano Menescal Pedrinha, Lucas Rafael Lopes, Phelippe Augusto Valente Maia, Jéssica Vilarinho Cardoso, Eduardo Branco de Sousa

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jamila Alessandra PeriniResearch Laboratory of Pharmaceutical Sciences (LAPESF), Pharmacy Department, Rio de Janeiro of State University (UERJ), Rio de Janeiro 23070-200, Brazil.ORCID 0000-0002-7683-0698
Igor Stefano Menescal PedrinhaKnee Surgery Center, National Institute of Traumatology and Orthopaedics (INTO), Rio de Janeiro 20940-070, Brazil.
Lucas Rafael LopesResearch Laboratory of Pharmaceutical Sciences (LAPESF), Pharmacy Department, Rio de Janeiro of State University (UERJ), Rio de Janeiro 23070-200, Brazil.
Phelippe Augusto Valente MaiaKnee Surgery Center, National Institute of Traumatology and Orthopaedics (INTO), Rio de Janeiro 20940-070, Brazil.
Jéssica Vilarinho CardosoResearch Laboratory of Pharmaceutical Sciences (LAPESF), Pharmacy Department, Rio de Janeiro of State University (UERJ), Rio de Janeiro 23070-200, Brazil.
Eduardo Branco de SousaGeneral and Specialized Surgery Department, Faculty of Medicine, Fluminense Federal University (UFF), Rio de Janeiro 24033-900, Brazil.ORCID 0000-0001-8577-6403

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq 301931/2025-9Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ E-26/211.498/2021; E-26/211.209/2021 and E-26/210.626/2024Universidade do Estado do Rio de Janeiro Prociencia UERJ 2023-2026 and Qualitec-Inovuerj 2023-2026
6 · The paper itself

Abstract

BACKGROUND/

objectivesKnee osteoarthritis (KOA) is a multifactorial and degenerative disease. Growth differentiation factor 5 (

methodsThis cross-sectional observational study enrolled 224 Brazilian patients with KOA, who were evaluated and classified according to disease severity.

resultsThe median age was 64 (44-84) years; 75.9% of the patients were female, 50.9% were shorter than 1.60 m, and 67.4% were obese or morbidly obese. The disease severity distribution was 64.7% grades I-III and 35.3% IV-V. Patients with KOA who were over 70 years had significantly more advanced grades (OR = 9.3; 95% CI = 3.4-26), in either female group (OR = 8.2; 95% CI = 2.6-26). The minor allele frequency of the

conclusionsThe

Indexed as

Body HeightGrowth Differentiation Factor 5Osteoarthritis, KneePolymorphism, Single NucleotideAdultAgedAged, 80 and overBrazilCross-Sectional StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedSeverity of Illness IndexGDF5 protein, humanGrowth Differentiation Factor 5cartilage degenerationgenetic variationgrowth differentiation factorrisk factorsingle nucleotide polymorphismsynovial inflammationtransforming growth factor beta

Identifiers

PMID41465193
PMCPMC12732996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.