ArticleInternational journal of molecular sciences2025
Triglyceride Accumulation in Adipocytes Modulated by Insulin Dynamics.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study examined how meal frequency under isocaloric conditions affects triglyceride accumulation in adipocytes, focusing on the role of insulin dynamics. Using a mathematical model of carbohydrate-lipid metabolism, we simulated feeding regimens from one to eight meals/day while holding calories and macronutrient ratios constant. A simplified model allowed independent variation in insulin peak amplitude, width, and overlap Results show that, relative to thrice-daily feeding (the reference regimen with stable triglyceride content over one month), infrequent meals (1-2/day) reduce, while frequent meals (5-8/day) increase triglyceride accumulation-most strongly in healthy individuals and attenuated in type 2 diabetes, as parameterized from the literature. Crucially, fat accumulation correlates not with average insulin levels but with its dynamic profile. Metabolic flux analysis revealed that triglyceride accumulation is driven not by changes in synthesis rate but by suppression of lipolysis, which depends on the amplitude, duration, and degree of overlap of insulin peaks. Thus, fat mass is shaped not only by caloric intake but by meal timing, which defines the insulin signal's temporal structure. These findings highlight that insulin dynamics-not mean concentration-govern lipid metabolism, urging dietary guidelines to account for meal pattern, not just composition or total energy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.