Evidence map›Paper›PMID 41465266›Full record

ArticleInternational journal of molecular sciences2025

Heteroaryl Bishydrazono Nitroimidazoles: A Unique Structural Skeleton with Potent Multitargeting Antibacterial Activity.

Zhen-Zhen Li, Cheng-He Zhou, Yi-Jin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhen-Zhen LiState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Frontiers Science Center for Cell Responses, College of Pharmacy, Nankai University, Tianjin 300071, China.
Cheng-He ZhouKey Laboratory of Applied Chemistry of Chongqing Municipality, Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.ORCID 0000-0003-3233-5465
Yi-Jin LiuState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, Frontiers Science Center for Cell Responses, College of Pharmacy, Nankai University, Tianjin 300071, China.

Funding

Chongqing Graduate Research Innovation Project CYS18114Key Project of Innovation Research 2035 Pilot Plan of Southwest University SWU-XDZD22007National Natural Science Foundation of China 82473771the Key Project of Tianjin Municipal Natural Science Foundation of China 24ZXZSSS00020
6 · The paper itself

Abstract

The emergence of bacterial infections as a critical public health challenge underscores the urgent need for innovative therapeutic strategies. We designed and synthesized a series of novel heteroaryl bishydrozono nitroimidazoles and their analogs by strategically hybridizing multiple molecular components through diverse linkers. Among the newly synthesized compounds, compound

Indexed as

Anti-Bacterial AgentsNitroimidazolesDNA GyraseHemolysisHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsReactive Oxygen SpeciesStructure-Activity RelationshipAnti-Bacterial AgentsDNA GyraseNitroimidazolesReactive Oxygen Speciesantibacterialdrug resistancehydrazoneimidazolemembranenitrofurantoin

Identifiers

PMID41465266
PMCPMC12733231

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.