Evidence mapPaperPMID 41465299Full record

ReviewInternational journal of molecular sciences2025

The Role of Gut Microbiota in Colorectal Cancer Pathogenesis: A Comprehensive Literature Review.

Dan Nicolae Paduraru, Alexandru Cosmin Palcau, Valeriu Gabi Dinca, Diana Mihaela Ciuc, Alexandru Constantinescu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  6. Review
  7. Review
  8. The evolving story ofFrontiers in microbiology · 2026
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dan Nicolae PaduraruFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Alexandru Cosmin PalcauFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0009-0009-5145-5404
Valeriu Gabi DincaSurgery Department, CF2 Clinical Hospital, 011464 Bucharest, Romania.
Diana Mihaela CiucOtolaryngology Department, CF2 Clinical Hospital, 011464 Bucharest, Romania.
Alexandru ConstantinescuFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0009-0007-1162-5777

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) represents a significant global health burden, ranking as the third most frequently diagnosed malignancy worldwide. Emerging evidence has established a compelling association between gut microbiota dysbiosis and CRC pathogenesis, revealing complex mechanisms through which specific bacterial communities modulate carcinogenesis. This comprehensive review synthesizes current knowledge on the mechanistic contributions of gut microbiota to CRC development, with particular emphasis on key pathogenic bacteria including

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeAnimalsCarcinogenesisDysbiosisHumanscarcinogenesiscolorectal cancerdysbiosisgut microbiotainflammationmicrobiome

Identifiers

PMID41465299
PMCPMC12733327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.