Evidence map›Paper›PMID 41465302›Full record

ArticleInternational journal of molecular sciences2025

An ATF3 Inducer Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease Through the AMPK and PKA Pathways.

Ching-Feng Cheng, Ruey-Bing Yang, Wen-Ting Chen, Jia-Fang Chung, Hui-Chen Ku

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ching-Feng ChengDepartment of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.ORCID 0000-0003-0104-0146
Ruey-Bing YangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-3017-3714
Wen-Ting ChenDepartment of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Jia-Fang ChungDepartment of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Hui-Chen KuDepartment of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.ORCID 0000-0001-5169-1292

Funding

National Science and Technology Council NSTC 113-2314-B-303-025-MY3;NSTC 114-2314-B-303-005Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation TCRD-TPE-NCU-113-01, TCMMP114-01-02,TCRD-TPE-NCU-114-01the collaborative grants from the Tzu Chi Medical Foundation, the Tzu Chi University, and Ac-ademia Sinica TCAS-112-02
6 · The paper itself

Abstract

Obesity is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), but the molecular mechanisms and effective treatments remain unclear. This study investigated whether ST32db, an inducer of activating transcription factor 3 (ATF3), affects lipid metabolism in MASLD. An in vitro model was established involving the treatment of HepG2 cells with 1 mM oleic acid (OA) with or without 20 µM ST32db. In an in vivo model, C57BL/6 mice were fed a high-fat diet (HFD) for 18 weeks to induce obesity and treated or not with ST32db (1 mg kg

Indexed as

Activating Transcription Factor 3AMP-Activated Protein KinasesCyclic AMP-Dependent Protein KinasesFatty LiverSignal TransductionAnimalsDiet, High-FatDisease Models, AnimalHep G2 CellsHumansLipaseLipid MetabolismLipogenesisLiverMaleMiceActivating Transcription Factor 3AMP-Activated Protein KinasesATF3 protein, humanAtf3 protein, mouseCyclic AMP-Dependent Protein KinasesLipaseactivating transcription factor 3 inducerAMP-activated protein kinaseMASLDprotein kinase A

Identifiers

PMID41465302
PMCPMC12732720

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.