Evidence map›Paper›PMID 41465339›Full record

ReviewInternational journal of molecular sciences2025

A Review on the Role of Oral Bacteria in Stroke.

Florencia Gayo, Jorge Moldes, Susana Bravo, Irene Vieitez, Lucía Martínez-Lamas, Manuel Rodríguez-Yáñez, Ramón Iglesias-Rey, Pedro Diz, Tomás Sobrino, Juan Blanco and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Florencia GayoUnit of Periodontology, Faculty of Dentistry and Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain.ORCID 0009-0000-6741-533X
Jorge MoldesFamily and Community Medicine Department, Bueu Health Centre, Pontevedra University Clinical Hospital, 36071 Pontevedra, Spain.ORCID 0009-0008-5939-9876
Susana BravoProteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital, 15706 Santiago de Compostela, Spain.ORCID 0000-0001-7615-3079
Irene VieitezGenomic Unit, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.ORCID 0000-0001-9241-0207
Lucía Martínez-LamasDepartment of Microbiology and Parasitology, Complexo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain.ORCID 0000-0001-9774-0045
Manuel Rodríguez-YáñezStroke Unit, Neurology Department, University Clinical Hospital, 15706 Santiago de Compostela, Spain.
Ramón Iglesias-ReyNeuroimaging and Biotechnology Laboratory Group, Clinical Neurosciences Research Laboratories, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital, 15706 Santiago de Compostela, Spain.ORCID 0000-0002-9985-9135
Pedro DizMedical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-1483-401X
Tomás SobrinoNeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-9760-8690
Juan BlancoUnit of Periodontology, Faculty of Dentistry and Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain.ORCID 0000-0001-9251-513X
Yago LeiraUnit of Periodontology, Faculty of Dentistry and Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain.

Funding

Biomedical Research Networking Center on Neurodegenerative Diseases CB22/05/00067European Union's Horizon 2020 research and innovation program 101066444Instituto de Salud Carlos III PI22/00938INTERREG Atlantic Area EAPA_791/2018_ NEUROATLANTIC projectINTER-REG V A España Portugal 0624_2IQBIONEURO_6_EXunta de Galicia IN607A2022/07Xunta de Galicia IN607D2024/003
6 · The paper itself

Abstract

Emerging evidence suggests periodontitis may contribute to stroke risk via vascular inflammation and endothelial dysfunction, promoting atherothrombosis and atrial fibrillation. This review aims to synthesize the evidence on the presence of oral bacteria and their products in biological samples from stroke patients and assess their potential impact on stroke pathophysiology, clinical outcomes, and prognosis. We conducted a narrative review of epidemiological, serological, and molecular studies examining the presence of oral bacterial DNA, endotoxins and antibodies against oral pathogens in biological samples (blood, saliva and thrombi) from stroke patients. Seropositivity for periodontal pathogens in blood was associated with incident stroke, as well as with poorer prognosis. Oral bacterial DNA, mainly from

Indexed as

BacteriaMouthPeriodontitisStrokeDNA, BacterialHumansDNA, Bacterialbacteriacerebral ischemiaperiodontitisstroke

Identifiers

PMID41465339
PMCPMC12732652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.