Evidence mapPaperPMID 41465341Full record

ArticleInternational journal of molecular sciences2025

Aqueous Extract of

Maribel Pérez-Rodríguez, Salvador Pérez-Mora, Marvin A Soriano-Ursúa, María Del Consuelo Gómez-García, Yazmin Montserrat Flores-Martinez, Juan Ocampo-López, Absalom Zamorano-Carrillo, José Manuel Viveros-Bartolomé, David Guillermo Pérez-Ishiwara

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maribel Pérez-RodríguezLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.
Salvador Pérez-MoraLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0009-0003-0282-9605
Marvin A Soriano-UrsúaLaboratorio de Neurofisiología, Escuela Superior de Medicina (ESM), Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón s/n, Mexico City 11340, Mexico.ORCID 0000-0002-6529-1502
María Del Consuelo Gómez-GarcíaLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0000-0002-7888-7700
Yazmin Montserrat Flores-MartinezLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0000-0001-9382-5316
Juan Ocampo-LópezLaboratorio de Histología e Histopatología, Área Académica de Medicina Veterinaria, Instituto de Ciencias Agropecuarias (ICAp), Universidad Autónoma del Estado de Hidalgo, Tulancingo de Bravo, Hidalgo 43600, Mexico.ORCID 0000-0002-9208-7216
Absalom Zamorano-CarrilloLaboratorio Biofísica Computacional, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.
José Manuel Viveros-BartoloméLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0000-0003-0156-0547
David Guillermo Pérez-IshiwaraLaboratorio de Biomedicina Molecular I, Escuela Nacional de Medicina y Homeopatía (ENMyH), Instituto Politécnico Nacional, Mexico City 07320, Mexico.ORCID 0000-0001-9368-3717

Funding

Instituto Politécnico Nacional 20201289Instituto Politécnico Nacional 20221123Instituto Politécnico Nacional 20250192
6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron degeneration in the substantia nigra and striatum. Current treatments are largely palliative and frequently associated with adverse effects. This study aimed to evaluate the neuroprotective potential of an aqueous extract of

Indexed as

BacopaNeuroprotective AgentsNF-E2-Related Factor 2Parkinson DiseasePlant ExtractsSignal Transduction1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsDisease Models, AnimalHeat Shock Transcription FactorsHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, Inbred C57BLOxidative StressSubstantia Nigra1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineHeat Shock Transcription FactorsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNeuroprotective AgentsNfe2l2 protein, mouseNF-E2-Related Factor 2Plant Extractsantioxidant enzymesBacopa procumbensfunctional enrichment analysisHIF-1αHSF1interactomic analysisKeap1/Nrf2/ARE pathwaylipid peroxidationMPTPNAPELneuroprotectionoxidative stressParkinson’s disease

Identifiers

PMID41465341
PMCPMC12733197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.