Evidence map›Paper›PMID 41465392›Full record

ArticleInternational journal of molecular sciences2025

Photobiomodulation-Driven Tenogenic Differentiation of MSCs in Hydrogel Culture.

Brendon Roets, Heidi Abrahamse, Anine Crous

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brendon RoetsLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, P.O. Box 17011, Johannesburg 2028, South Africa.ORCID 0000-0002-9618-9340
Heidi AbrahamseLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, P.O. Box 17011, Johannesburg 2028, South Africa.ORCID 0000-0001-5002-827X
Anine CrousLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, P.O. Box 17011, Johannesburg 2028, South Africa.ORCID 0000-0002-7581-7731

Funding

Department of Science and Innovation (DSI) funded African Laser Centre (ALC) HLHA26X task ALC-R003Department of Science and Innovation's South African Research Chairs Initiative (DSI-NRF/SARChI) 98337National Research Foundation of South Africa Thuthuka Instrument TTK2205035996South African Medical Research Council 57050University Research Council 2024URC00813
6 · The paper itself

Abstract

Tendon healing is limited by hypocellularity and low metabolic activity, resulting in poor regeneration. Mesenchymal stem cells (MSCs) offer potential for tendon repair, but reliable tenogenic differentiation protocols remain undefined. Photobiomodulation (PBM) has been proposed as an adjunct to assist differentiation, yet standardized parameters are lacking, particularly in 3D systems. This study evaluated the effects of PBM at 525 nm, 825 nm, and combined wavelengths, delivered at 5 J/cm

Indexed as

Cell DifferentiationHydrogelsLow-Level Light TherapyMesenchymal Stem CellsTendonsCell Culture TechniquesCell ProliferationCells, CulturedHumansHydrogels3D cell culturehydrogelphotobiomodulationtenocytes and iADMSCstenogenic differentiation

Identifiers

PMID41465392
PMCPMC12732497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.