Evidence map›Paper›PMID 41465416›Full record

ArticleInternational journal of molecular sciences2025

Proline-, Glutamic Acid-, Leucine-Rich Protein 1 (PELP1): Diversity, Structural Conservation, and Evolutionary Origins Across the Species.

Nomfundo Mngomezulu, Siphesihle M Msweli, Suresh B Pakala, Khajamohiddin Syed

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nomfundo MngomezuluDepartment of Biochemistry and Microbiology, Faculty of Science, Agriculture and Engineering, University of Zululand, Empangeni 3886, South Africa.ORCID 0000-0003-2206-6388
Siphesihle M MsweliDepartment of Biochemistry and Microbiology, Faculty of Science, Agriculture and Engineering, University of Zululand, Empangeni 3886, South Africa.ORCID 0000-0002-2100-7928
Suresh B PakalaDepartment of Biochemistry and Microbiology, Faculty of Science, Agriculture and Engineering, University of Zululand, Empangeni 3886, South Africa.ORCID 0000-0002-5679-4837
Khajamohiddin SyedDepartment of Biochemistry and Microbiology, Faculty of Science, Agriculture and Engineering, University of Zululand, Empangeni 3886, South Africa.ORCID 0000-0002-1497-3570

Funding

National Research Foundation (NRF), South Africa KIC250328307046National Research Foundation (NRF), South Africa PMDS230527110616
6 · The paper itself

Abstract

Proline-, Glutamic acid-, Leucine-rich Protein 1 (PELP1) is a multifunctional nuclear protein essential for ribosome biogenesis and steroid receptor signaling. It contains two hallmark domains: the RIX1 (Ribosome Export 1) domain, which mediates rRNA processing, and the NUC (nucleolar) domain, associated with nucleolar function. While PELP1's biological roles are well-characterized in mammals, particularly

Indexed as

Co-Repressor ProteinsEvolution, MolecularAmino Acid SequenceAnimalsConserved SequenceHumansPhylogenyProtein DomainsTranscription FactorsCo-Repressor ProteinsPELP1 protein, humanTranscription FactorsNUC domainNuclear Localization Signalphylogenetic analysisRIX1 domainscaffolding protein

Identifiers

PMID41465416
PMCPMC12733202

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.