ArticleInternational journal of molecular sciences2025
BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling Pathways.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Hiroki YokooDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Yu-Ichiro KomaDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0002-3022-8466
Naozane NomuraDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.ORCID 0009-0007-0700-058X
Rikuya TorigoeDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.ORCID 0009-0006-5679-5465
Masaki OmoriDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Takashi NakanishiDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Shoji MiyakoDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0002-1081-0379
Takaaki NakanishiDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Takayuki KodamaDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Manabu ShigeokaDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Yoshihiro KakejiDivision of Gastro-Intestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.ORCID 0000-0002-2727-0241
Masafumi HorieDivision of Molecular and Genomic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.
Funding
Japan Society for the Promotion of Science 22K06978 and 25K10263
6 · The paper itself
Abstract
Esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis due to aggressive invasion and therapy resistance. Cancer-associated fibroblasts (CAFs) are key stromal components that promote tumor progression; however, their specific roles in ESCC remain unclear. Using a direct co-culture model of ESCC cell lines (TE-9, -10, and -15) and mesenchymal stem cells (MSCs) to generate CAF-like cells, we identified biglycan (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling Pathways. · full record | Socratic