Evidence mapPaperPMID 41465469Full record

ReviewInternational journal of molecular sciences2025

Molecular Mechanisms Driving Precision Medicine in Perioperative Care: Integrating Inflammation, Metabolism, and Neuroimmunomodulation for Personalized Outcomes.

Ann-Kathrin Wenner, Lukas Andereggen, Markus M Luedi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ann-Kathrin WennerDepartment of Anaesthesiology, Rescue- and Pain Medicine, Cantonal Hospital of St. Gallen, 9007 St. Gallen, Switzerland.
Lukas AndereggenDepartment of Neurosurgery, Kantonsspital Aarau, 5001 Aarau, Switzerland.ORCID 0000-0003-1764-688X
Markus M LuediDepartment of Anaesthesiology, Rescue- and Pain Medicine, Cantonal Hospital of St. Gallen, 9007 St. Gallen, Switzerland.ORCID 0000-0002-9049-2584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision perioperative medicine connects mechanisms across inflammation, metabolism, and neuroimmunomodulation to predict risk and individualize therapy. This review aims to incorporate landmark concepts and recent studies (2017-2025) as well as outlining how multi-omics and clinical analytics translate biology into actionable pathways. Key opportunities include cytokine-guided risk stratification, metabolic conditioning, and autonomic neuromodulation targeting the cholinergic anti-inflammatory reflex. Implementation requires robust phenotyping, interoperable data pipelines, and trials focused on functional recovery and cognition.

Indexed as

InflammationNeuroimmunomodulationPerioperative CarePrecision MedicineAnimalsHumansdata-driven perioperative pathwaysimmunometabolismperioperative stress responsepersonalized medicinesurgical resiliencetranslational medicine

Identifiers

PMID41465469
PMCPMC12733346

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.