Evidence map›Paper›PMID 41465477›Full record

ArticleInternational journal of molecular sciences2025

Glucocorticoid Signaling-Associated Gene Expression in the Hippocampus and Frontal Cortex of Chronically Isolated Normotensive and Hypertensive Rats and the Responsiveness to Acute Restraint Stress.

Alexey Kvichansky, Liya Tretyakova, Yulia Moiseeva, Viktoriia Ovchinnikova, Diana Mamedova, Olga Nedogreeva, Natalia Lazareva, Natalia Gulyaeva, Mikhail Stepanichev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexey KvichanskyInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0002-0490-1995
Liya TretyakovaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0001-5053-5706
Yulia MoiseevaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Viktoriia OvchinnikovaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Diana MamedovaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Olga NedogreevaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0002-6845-0089
Natalia LazarevaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Natalia GulyaevaInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0002-5380-7954
Mikhail StepanichevInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.ORCID 0000-0001-8109-8692

Funding

Russian Science Foundation 22-15-00132-P
6 · The paper itself

Abstract

Genotypic characteristics may determine the body's response to stressful conditions as well as its susceptibility to cardiovascular diseases and stroke. Old age worsens the course of these diseases, and often concomitant hypertension can negatively affect brain function, especially in cases of social isolation. In this work, we studied how social isolation and hypertension affect the transcription activity of genes associated with glucocorticoid signaling in the rat brain. The study was performed on 10-month-old rats of the outbred Wistar stock (

Indexed as

Frontal LobeGlucocorticoidsHippocampusHypertensionSignal TransductionStress, Psychological11-beta-Hydroxysteroid Dehydrogenase Type 1AnimalsBlood PressureCorticosteroneGene Expression RegulationMaleRatsRats, Inbred SHRRats, WistarReceptors, Glucocorticoid11-beta-Hydroxysteroid Dehydrogenase Type 1CorticosteroneGlucocorticoidsReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding Proteinscorticosteronefrontal cortexgene expressionhippocampushypothalamus–pituitary–adrenal systemsocial isolationsympatho-adrenal system

Identifiers

PMID41465477
PMCPMC12732442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.