Evidence map›Paper›PMID 41465503›Full record

ArticleInternational journal of molecular sciences2025

Catalytically Active Recombinant Cysteine Proteases of

Athira C Karunakaran, Mariam Bakshi, Arunraj M Rajendrakumar, Jennifer H Wilson-Welder, Raffi V Aroian, Erich M Schwarz, E Jane Homan, Gary R Ostroff, Ethiopia Beshah, Eliseo Miramontes and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Athira C KarunakaranAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Mariam BakshiAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Arunraj M RajendrakumarAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.ORCID 0000-0003-4290-7682
Jennifer H Wilson-WelderInfectious Bacterial Diseases Research Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010, USA.
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Erich M SchwarzDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3151-4381
E Jane HomanioGenetics LLC, Madison, WI 53704, USA.
Gary R OstroffProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Ethiopia BeshahAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Eliseo MiramontesAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Marianne Dias PapadopoulosAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Scott A BowdridgeDavis College of Agriculture and Natural Resources, Morgantown, WV 26506, USA.
Dante S ZarlengaAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Xiaoping ZhuDepartment of Veterinary Medicine, University of Maryland, College Park, MD 20740, USA.
Wenbin TuoAnimal Parasitic Diseases Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.ORCID 0000-0002-3764-8981

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
A dual-purpose vaccine targeting blood-feeding nematode parasites of sheep and humansR01HD099072 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2019 to 2023
$2.4M
National Institute of Health, USA R01HD099072-05NIAID NIH HHS R01 AI056189NICHD NIH HHS R01 HD099072United States Department of Agriculture 5030-3200-223-00DUnited States Department of Agriculture 8042-32000-116-000
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blood CoagulationBlood ProteinsCysteine ProteasesHaemonchusHelminth ProteinsAnimalsCattleHaemonchiasisProteolysisRecombinant ProteinsBlood ProteinsCysteine ProteasesHelminth ProteinsRecombinant Proteinsblood clottingcathepsin Bcysteine proteasesfibrinogengastrointestinal nematodeHaemonchus contortusrecalcification time assay

Identifiers

PMID41465503
PMCPMC12732675

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.