Evidence map›Paper›PMID 41465559›Full record

ArticleInternational journal of molecular sciences2025

Dietary Geranylgeraniol Mitigates Pain-Associated Behaviors via Improving Mitochondrial Function and Colon Integrity and Suppressing Neuroinflammation in Male Diabetic Neuropathy Rats.

Chwan-Li Shen, Xiaobo Liu, Jay J Cao, Volker Neugebauer, Jonathan M Miranda, Moamen M Elmassry, Dale M Dunn, Jannette M Dufour

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chwan-Li ShenDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-9595-6598
Xiaobo LiuDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0002-2492-4537
Jay J CaoGrand Forks Human Nutrition Research Center, U.S. Department of Agriculture-Agricultureal Research Service (USDA-ARS), Grand Forks, ND 58202, USA.
Volker NeugebauerCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Jonathan M MirandaDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Moamen M ElmassryDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
Dale M DunnDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Jannette M DufourCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-5623-519X

Funding

NIH HHS R01NS038261 (VN)Robert A. Welch Foundation B1-0028, JMDUSDA-ARS #3062-10700-002-000D
6 · The paper itself

Abstract

Growing evidence highlights the links between diabetic neuropathy (DNP), gut dysbiosis, mitochondrial dysfunction and neuroinflammation in colon and bone microstructure deterioration. Geranylgeraniol (GG) shows neuroprotective and osteoprotective capacity. Our study examines GG's effects on pain-associated behaviors, glucose homeostasis, gut microbiota, mitochondrial homeostasis, and bone microstructure in DNP rats. We randomly assigned 27 male Sprague Dawley rats to three groups (

Indexed as

ColonDiabetic NeuropathiesDiterpenesMitochondriaNeuroinflammatory DiseasesPainAnimalsBehavior, AnimalDiabetes Mellitus, ExperimentalGastrointestinal MicrobiomeMaleRatsRats, Sprague-DawleyDiterpenesbehaviorsbraindiabetic neuropathygeranylgeraniolgut microbiomemitochondria homeostasisrats

Identifiers

PMID41465559
PMCPMC12733174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.