Evidence map›Paper›PMID 41465610›Full record

ArticleInternational journal of molecular sciences2025

Nephroprotective Effects of Quercetin-Selenium Nanoparticles Against Glycerol-Induced AKI.

Ahmed M Ashour, Ali Khames, Khaled M Alam-ElDein, Ahmed Hassan Ibrahim Faraag, Nievin Ahmed Mahran, Badriyah Aljazzaf, Rabia Alghazeer, Fatma Akmal, Marwa Ahmed Mahmoud, Mohamed H A Gadelmawla

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2026
    Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed M AshourDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, P.O. Box 13578, Makkah 21955, Saudi Arabia.ORCID 0000-0002-2118-0499
Ali KhamesDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82511, Egypt.
Khaled M Alam-ElDeinMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Cairo 11829, Egypt.ORCID 0009-0002-1140-8338
Ahmed Hassan Ibrahim FaraagMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Cairo 11829, Egypt.ORCID 0000-0002-2568-6059
Nievin Ahmed MahranDepartment of Biochemistry, Faculty of Biotechnology, Sinai University, Kantara Branch, Ismailia 41636, Egypt.
Badriyah AljazzafDepartment of Food Sciences and Nutrition, College of Health Sciences, The Public Authority for Applied Education and Training, Kuwait City 13092, Kuwait.
Rabia AlghazeerChemistry Department, Faculty of Science, University of Tripoli, Tripoli 50676, Libya.ORCID 0000-0002-1361-2933
Fatma AkmalHuman Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Marwa Ahmed MahmoudDepartment of Medical Physiology, Faculty of Medicine, Sohag University, Sohag 82511, Egypt.
Mohamed H A GadelmawlaDepartment of Life Sciences, Faculty of Biotechnology, Sinai University, Kantara Branch, Ismailia 41636, Egypt.ORCID 0000-0002-1976-9480

Funding

Umm al-Qura University 25UQU4310007GSSR05
6 · The paper itself

Abstract

Acute kidney injury (AKI) is defined as a quick and often reversible decline in renal performance, as shown by elevated creatinine or reduced urine volume. AKI is a common illness, particularly among hospitalized cases, and can be observed in up to 7% of hospital admissions and 30% of ICU admissions. This study was designed to explore the nephroprotective potential of eco-synthesized quercetin-selenium nanoparticles (QUR-SeNPs) against experimentally glycerol-induced rhabdomyolysis leading to AKI. Forty healthy adult male albino rats were employed in the experiment. Animals were randomly distributed equally into five groups: Control: orally administered with normal saline solution. GLY: orally administered with normal saline (0.9% NaCl) for 15 consecutive days, at day 14, animals of this group received a single dose of intramuscular (im.) injection of 50% glycerol (GLY) (10 mg/kg/day). GLY and quercetin (GLY&QUR): orally administered with quercetin daily for 15 days (50 mg/kg/day), at day 14, animals of this group received a single dose of im. injection of 50% glycerol (10 mg/kg/day). GLY&Na

Indexed as

Acute Kidney InjuryGlycerolNanoparticlesProtective AgentsQuercetinSeleniumAnimalsAntioxidantsKidneyMaleOxidative StressRatsAntioxidantsGlycerolProtective AgentsQuercetinSeleniumapoptosisinflammationoxidative stressquercetinrenal injuryselenium

Identifiers

PMID41465610
PMCPMC12733762

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.