Evidence map›Paper›PMID 41465616›Full record

ReviewInternational journal of molecular sciences2025

The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer.

Mario Macia Guardado, Valentina Lutz, Markus Hengstschläger, Helmut Dolznig

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Stage-Dependent Role of Eicosanoids in Colorectal Cancer.International journal of molecular sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mario Macia GuardadoCenter of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Waehringer Strasse 10, 1090 Vienna, Austria.
Valentina LutzCenter of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Waehringer Strasse 10, 1090 Vienna, Austria.
Markus HengstschlägerCenter of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Waehringer Strasse 10, 1090 Vienna, Austria.
Helmut DolznigCenter of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Waehringer Strasse 10, 1090 Vienna, Austria.ORCID 0000-0002-6063-3585

Funding

European Union, H2020-MSCA-ITN-2019 #859962"Initiative Krebsforschung" grant 2021 n.a.internal institutional funding n.a.
6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality, with inflammation playing a pivotal role in its pathogenesis. Chronic inflammation in the intestine significantly increases the risk of CRC development. Main compounds participating in the inflammatory process are prostaglandins; bioactive lipids derived from arachidonic acid metabolism via the cyclooxygenase (COX) pathway. While it is well known that prostaglandin E

Indexed as

Colorectal NeoplasmsInflammation MediatorsProstaglandinsAnimalsHumansInflammationSignal TransductionTumor MicroenvironmentInflammation MediatorsProstaglandinscolorectal cancerinflammationmicroenvironmentprostaglandins

Identifiers

PMID41465616
PMCPMC12734000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.