ArticleMedicine2025
Association of birth weight with lung function and the mediating role of gut microbiota: A STROBE 2-step Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence has suggested that low birth weight (LBW) influences lung function deficit in adulthood. The aim of this study was to examine the relationship between LBW and adult lung function deficit and to explore the potential mediating effect of the gut microbiota in this relationship. Using summary data from genome-wide association studies, we applied 2-sample Mendelian randomization to investigate the association between birth weight and adult lung function deficit. Various MR analysis methods were used, including the inverse variance weighted, MR-Egger, weighted median, simple mode and weighted mode. Furthermore, a mediation analysis was performed to identify the potential mediating role of 412 known bacterial microbiota. This study identified significant genetic associations between birth weight and forced vital capacity, forced expiratory volume in 1-s (FEV1), FEV1/forced vital capacity ratio, and lung volume. In addition, a 2-step MR analysis indicated that the effect of LBW on lung function was mediated by specific gut microbiota, including g_Blautia, s_Subdoligranulum_unclassified, and s_Ruminococcus_obeum. LBW is associated with adult lung function deficit, with gut microbiota partially mediating this relationship. These findings provide important insights for the prevention of lung function impairment in individuals with LBW.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.