Evidence map›Paper›PMID 41466023›Full record

ArticleScientific reports2025

Plasma catecholamine metabolites are associated with disease activity and pathophysiological features in systemic lupus erythematosus using targeted LC-MS/MS.

Binghui Li, Junpeng Zhao, Zhenni Liu, Bingchu Li, Zhiyang Chen, Ziyang Li, Xing Lyu, Zhe Guo, Weimin Wu, Li Tan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Binghui LiDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Junpeng ZhaoDepartment of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhenni LiuDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bingchu LiDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiyang ChenDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ziyang LiDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xing LyuDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhe GuoDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Weimin WuDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li TanDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min Hu *Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. huminjyk@csu.edu.cn.
Qichen Long *Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. qclong@csu.edu.cn.

Funding

Graduate Research and Innovation Project of Central South University (Independent exploration) No. 2022ZZTS0886the Hunan Health Commission Research Project (General Program) 20256933the National Natural Science Foundation of China 82302586the National Natural Science Foundation of China 82502192the Youth Science Foundation of Xiangya Hospital 2024Q17
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) presents diagnostic and disease monitoring challenges due to its heterogeneity and variable activity. In this cross-sectional study, we investigated the association of plasma catecholamine (CA) metabolites with SLE status and disease activity. Plasma samples from 88 SLE patients and 64 healthy controls were analyzed using targeted liquid chromatography-tandem mass spectrometry to quantify dopamine (DA), epinephrine (E), norepinephrine (NE), 3-methoxytyramine (3MT), metanephrine (MN), and normetanephrine (NMN). Significant alterations in CA metabolites levels were observed in SLE patients compared to controls, independent of glucocorticoid treatment. Orthogonal partial least squares-discriminant analysis (OPLS-DA) suggested distinct metabolic profiles in active SLE. NE, NMN, MN, and E showed notable group differences and correlations with inflammatory markers, clinical features, complement levels, and SLE Disease Activity Index (SLEDAI) scores. Receiver operating characteristic analysis demonstrated strong diagnostic performance for individual CA biomarkers, while combined plasma CA metabolites assessment yielded superior predictive capability for SLE activity (AUC: 0.866, 95% CI: 0.785–0.947). These findings highlight the potential of plasma CA metabolites, particularly NE and NMN, are associated with SLE disease activity and may serve as potential associative biomarkers. Further validation in independent and longitudinal cohorts is warranted.

Indexed as

CatecholaminesLupus Erythematosus, SystemicAdultBiomarkersCase-Control StudiesChromatography, LiquidCross-Sectional StudiesFemaleHumansLiquid Chromatography-Mass SpectrometryMaleMiddle AgedROC CurveTandem Mass SpectrometryBiomarkersCatecholaminesBiomarkerCatecholamineLC-MS/MSMetabolitesSystemic lupus erythematosus

Identifiers

PMID41466023
PMCPMC12800218

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.