ArticleBMC women's health2025
Association between depression, sleep disturbance, and irregular menstrual cycles: insights from the NHANES 2005-2018.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Beyond the Mesh: PuboUrethral Ligament Plication Versus Transobturator Tape at 6 Months and the Power of Preoperative ICIQ-SF for Risk Stratification.International urogynecology journal · 2026Article
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5 authors.
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Abstract
introductionThis paper examines the connection among sleep disturbances, depressive symptoms, and menstrual cycle irregularities. Given the high prevalence of sleep disturbances and depression among women of reproductive age, understanding their impact on menstrual cycles is crucial for developing effective interventions.
methodsNHANES data of American women from 2005 to 2018 were utilized. Weighted multivariate logistic regression models were utilized to estimate the odds of menstrual irregularities in relation to depressive symptoms, sleep disturbances, and their combined effects. Restricted cubic spline analyses were used to assess potential nonlinear relationships. Subgroup analyses were conducted based on demographic and lifestyle factors. Mediation analysis was performed to evaluate the potential indirect pathways through fasting blood glucose (FBG) and triglycerides (TG).
resultsThree thousand five hundred ninety-four participants were included in adjusted analyses. Both depressive symptoms (OR = 1.58; 95% CI: 1.13-2.23) and sleep disturbance (OR = 1.69; 95% CI: 1.23-2.34; P = 0.002) were associated with higher odds of menstrual irregularities. Participants with both sleep disturbances and depressive symptoms had higher odds of menstrual irregularities (OR = 1.86; 95% CI: 1.29-2.67; P = 0.001). In mediation analyses, the indirect association via FBG accounted for 1.56% of the total association, and the indirect association via TG accounted for 4.31%.
conclusionSleep disturbances and depressive symptoms were independently and jointly associated with higher odds of menstrual irregularities, and the risk was higher when both were present. Statistically significant indirect associations were observed via FBG and TG.
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