ArticleBMC endocrine disorders2025
Association between the triglyceride glucose-waist-to-height ratio and stroke risk among middle-aged and elderly Chinese adults.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe correlation between the triglyceride glucose-waist-to-height ratio (TyG-WHtR) and the risk of stroke has not been extensively explored. This research aimed to examine the correlation between TyG-WHtR and the occurrence of stroke among middle-aged and elderly individuals in the Chinese demographic.
methodsThis prospective study included 8618 subjects from the China Health and Retirement Longitudinal Study (CHARLS). Multivariate Cox regression models were applied to test the effect of TyG-WHtR on stroke. Nonlinear associations were examined using restricted cubic spline (RCS) models.
resultsThe average age of the adults was 59.38 ± 9.28 years, with 3978 (46.16%) being male. During a median follow-up duration of seven years, stroke was diagnosed in 995 (11.55%) individuals. In a multivariable model, TyG-WHtR exhibited a significant positive association with stroke (HR: 1.20, 95%CI: 1.04–1.38, p = 0.0140). RCS models identified a nonlinear correlation (inflection point at TyG-WHtR = 4.87). For values below 4.87, TyG-WHtR was significantly related to stroke (HR: 1.45, 95%CI: 1.17–1.80, p = 0.0007). Above 4.87, no significant correlation remained (HR: 1.03, 95%CI: 0.85–1.25, p = 0.7530).
conclusionOur research revealed a positive, non-linear association between the TyG-WHtR and stroke risk. Specifically, a significant positive association was observed when the TyG-WHtR was below 4.87. These findings provide valuable insights that could enhance clinical consultations and inform the optimization of stroke prevention strategies in middle-aged and older adults. CLINICAL TRIAL NUMBER: Not applicable.
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