ArticleEye and brain2025
Macular Pigment Carotenoid Supplementation for the Preservation of Visual Structure and Function Following a Collegiate Rugby Season.
Article in Eye and brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Introduction: Repetitive head impacts (RHIs) and visual system dysfunction are often associated. Interventions to prevent or limit visual deficits following RHIs are not well understood. This study examined visual structure and function following exposure to RHIs and the effectiveness of a supplemental intervention of macular pigment carotenoids (MPCs) and omega-3 fatty acids in attenuating visual changes from pre- to post-season in collegiate rugby players. Additionally, blood biomarkers associated with neurodegeneration were examined. Methods: Optical coherence tomography measured visual structure through ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness. Bioavailability of the supplement was assessed through skin carotenoid concentration (SC). Contrast sensitivity (CS) and critical flicker-fusion frequency (CFF) were used to measure visual function. NF-L, GFAP, Tau, and UCH-L1 concentrations in blood samples were analyzed. Results: Thirty-one rugby players (15M/16F; 19±1.4 years) were randomly assigned to supplement (n = 15) or placebo (n = 16) groups. Left eye GCC inferior region was thinner at post-season in supplement (102.1±4.4 vs 102.9±4.7 μm;
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