ReviewJournal of inflammation research2025
Ferroptosis in Hypertriglyceridemic Acute Pancreatitis: Mechanisms and Therapeutic Implications.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Phenyllactic Acid Restores Intestinal Epithelial Barrier to Alleviate Hypertriglyceridemic Acute Pancreatitis via a PPARγ-Dependent Mechanism.Antioxidants (Basel, Switzerland) · 2026Article
- Deep chemical structure graph learning deciphers the lipotoxicity code of hypertriglyceridemic pancreatitis.NPJ digital medicine · 2026Article
- Neuromodulatory Interventions in Experimental Acute Pancreatitis: A Systematic Review of Rodent Studies.Diseases (Basel, Switzerland) · 2026Review
- Ion channels and GPCRs as pharmacological regulators of ferroptosis and pyroptosis in metabolic diseases.Diabetology & metabolic syndrome · 2026Review
- TRIM62 promotes osteoarthritis progression by facilitating GPX4 ubiquitination and chondrocyte ferroptosis.American journal of translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis, a iron-dependent programmed cell death characterized by iron-dependent accumulation of lipid peroxidation to lethal levels, is closely related to the pathogenesis of hypertriglyceridemic acute pancreatitis, a condition marked by lipid metabolism disorders. This paper summarizes the latest research progress in understanding the mechanistic contributions on the mechanisms of ferroptosis in HTG-AP, with a particular focus on the roles of lipid peroxidation and iron-catalyzed reactive oxygen species generation in the pathogenesis and progression of HTG-AP. It further elaborates on critical molecules-including the GPX4, ACSL4, SLC7A11 and FSP1-CoQ10-NAD(P)H and key cellular signaling pathways-including the HIF pathways, JAK-STAT pathways, PI3K/ Akt pathways closely linked to ferroptosis in HTG-AP. Understanding the pathophysiological role of hypertriglyceridemia in pancreatic injury is essential for unraveling the complex interplay between lipid and iron metabolic homeostasis. Additionally, by integrating evidence from preclinical models and human studies, this review emphasizes the importance of ferroptosis mechanisms in the treatment of HTG-AP, with the goal of identifying potential therapeutic targets and proposing innovative intervention strategies aimed at mitigating ferroptosis, potentially improving outcomes in HTG-AP.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.