ReviewMolecular therapy. Nucleic acids2025
MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases.
Review in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- MicroRNA-Ferroptosis-Spinal Cord Injury: A Complex Interplay in Neurodegeneration and Repair.International journal of molecular sciences · 2026Review
- Investigating the Role of microRNA in Host-Influenza A and Other Respiratory RNA Virus Interactions.Pathogens (Basel, Switzerland) · 2026Review
- Integrated Analysis of mRNA and microRNA Expression in Corneal Impression Cytology Samples from Patients withInternational journal of molecular sciences · 2026Article
- Beyond Coding Variants: RNA-Level Mechanisms in Human Disease and Precision Therapeutics.Genes · 2026Review
- Molecular basis of precision nutrition: Food components, microbiome-derived metabolites, and multi-omics modeling.Food chemistry. Molecular sciences · 2026Review
- Neuropathic Pain: Mapping the miRNA Landscape.Non-coding RNA · 2026Review
- The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS pharmacology & translational science · 2026Review
- Unraveling the influence of TGF-β rs9282871 and miRNA let-7c relative expression on TGF-β production in hepatocellular carcinoma patients.Journal, genetic engineering & biotechnology · 2026Article
- Integrative analysis ofFrontiers in plant science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small, non-coding RNAs that influence various cellular activities through post-transcriptional gene silencing. Recent research has shown that miRNA modifications, including N6-methyladenosine (m6A), 5-methylcytidine (m5C), 2'-O-methylation (Nm), N7-methylguanosine (m7G), pseudouridylation (Ψ), phosphorylation, RNA editing (adenosine to inosine [A to I]), acetylation, and oxidation, play crucial roles in fine-tuning miRNA expression and function. This review examines the impact of nucleotide modifications on miRNA biogenesis, particularly their role in regulating RNA interactions with the Drosha-DiGeorge syndrome critical region 8 (DGCR8) and Dicer complexes, thereby influencing primary miRNA (pri-miRNA) processing, pre-miRNA export, and miRNA maturation. It also examines whether these modifications assist miRNA recognition by RNA-binding proteins (RBPs) in controlling miRNA processing and stability, as well as their impact on miRNA strand selection, target recognition, and the recruitment of regulatory proteins to the miRNA-induced silencing complex (miRISC), which facilitates the silencing of miRNA-targeted messenger RNAs (mRNAs). Additionally, the review discusses the role of miRNA modifications in various human diseases and considers how advanced sequencing technologies and chemical biology approaches enable detailed mapping of these modifications. Furthermore, it provides new insights into the challenges of understanding the dynamic nature of miRNA modifications and their context-dependent effects. It also highlights future directions, including innovative detection methods and epigenetic crosstalk with potential therapeutic applications in human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.