Evidence map›Paper›PMID 41467406›Full record

ArticleJournal of the American Heart Association2026

Twenty-Four-Hour Central Ambulatory Blood Pressure: Relationship With Measures of Cardiovascular Subclinical Organ Damage in Healthy Individuals.

Ing Ni Lu, Shikai Yu, Gisele J Bentley, Barry J McDonnell, Navazh Jalaludeen, Kaisa M Mäki-Petäjä, Joseph Cheriyan, Ian B Wilkinson, Carmel M McEniery

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Urinary sodium and right ventricular function in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ing Ni LuClinical Pharmacology and Therapeutics Cambridge University Hospitals NHSFT Cambridge UK.ORCID 0000-0003-2336-6550
Shikai YuDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.ORCID 0000-0003-4879-0489
Gisele J BentleyDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.
Barry J McDonnellCardiff School of Sport and Health Sciences Cardiff Metropolitan University Cardiff UK.ORCID 0000-0001-5912-1278
Navazh JalaludeenClinical Pharmacology and Therapeutics Cambridge University Hospitals NHSFT Cambridge UK.
Kaisa M Mäki-PetäjäDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.
Joseph CheriyanDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.ORCID 0000-0001-6921-1592
Ian B WilkinsonDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.ORCID 0000-0001-6598-9399
Carmel M McEnieryDivision of Experimental Medicine and Immunotherapeutics University of Cambridge UK.ORCID 0000-0003-3636-0705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn most, but not all, observational studies, ambulatory central systolic blood pressure (cSBP) is more closely related to left ventricular mass index than ambulatory brachial SBP. However, the association with other markers of subclinical organ damage is poorly understood. We investigated the association between ambulatory brachial SBP or cSBP and measures of subclinical organ damage, together with the influence of waveform calibration method, in a large community-based population of untreated individuals.

methodsIn all, 1311 participants (mean age, 45±18 years; 589 women) had simultaneous measurements of ambulatory brachial and central pressure over 24 hours. Of these, left ventricular mass index was assessed in 675 individuals, carotid intima-media thickness in 610 individuals and carotid-femoral (aortic) pulse-wave velocity in 1091 individuals.

resultsLeft ventricular mass index was most strongly associated with cSBP, calibrated using mean and diastolic blood pressure, with a β coefficient of 0.237 (95% CI, 0.225-0.453;

conclusionsAmbulatory cSBP may provide valuable additional information concerning cardiovascular risk, although the method of waveform calibration exerts a marked impact.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesHypertrophy, Left VentricularAdultAgedBrachial ArteryCarotid-Femoral Pulse Wave VelocityCarotid Intima-Media ThicknessFemaleHumansMaleMiddle AgedPredictive Value of TestsPulse Wave AnalysisTime Factorsambulatory brachial systolic blood pressureambulatory central systolic blood pressureaortic pulse‐wave velocitycarotid intima‐media thicknessleft ventricular mass index

Identifiers

PMID41467406
PMCPMC12909030

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.