Evidence map›Paper›PMID 41468295›Full record

ArticleeLife2025

Epidermal resident memory T cell fitness requires antigen encounter in the skin.

Eric S Weiss, Toshiro Hirai, Haiyue Li, Andrew Liu, Shannon Baker, Ian Magill, Jacob Gillis, Youran R Zhang, Torben Ramcke, Kazuo Kurihara and 7 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Eric S WeissDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.ORCID https://orcid.org/0000-0003-2352-0036
Toshiro HiraiInstitute for Microbial Diseases, Osaka University, Osaka, Japan.
Haiyue LiDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Andrew LiuDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Shannon BakerDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Ian MagillDepartment of Immunology, Harvard Medical School, Boston, United States.
Jacob GillisDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Youran R ZhangDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Torben RamckeDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
Kazuo KuriharaDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.
ImmGen Consortium OpenSource T cell Project
David MasopustCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, United States.
Niroshana AnandasabapathyDepartment of Dermatology, Meyer Cancer Center, Program in Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, United States.
Harinder SinghDepartment of Immunology, University of Pittsburgh, Pittsburgh, United States.
David ZemmourDepartment of Immunology, Harvard Medical School, Boston, United States.
Laura K MackayDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Daniel H KaplanDepartment of Dermatology, University of Pittsburgh, Pittsburgh, United States.ORCID https://orcid.org/0000-0003-0598-0047

Funding

Regulated Activation of Latent-TGFb Determines Leukocyte Occupancy of the Epidermal NicheR01AR060744 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2011 to 2020
$4.0M
Intrinsic and Extrinsic factors regulating competition for active TGFb promote skin memory CD8 T cell fitnessR01AR083713 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel H Kaplan, HARINDER SINGH · 2024 to 2026
$1.7M
NIAMS NIH HHS AR083713NIAMS NIH HHS R01 AR060744NIAMS NIH HHS R01 AR083713NIH HHS 2T32AI060525NIH HHS 5R01AR060744NIH HHS 5R01 AR083208NIH HHS 5T32AI089443
6 · The paper itself

Abstract

CD8

Indexed as

AntigensCD8-Positive T-LymphocytesEpidermisImmunologic MemoryMemory T CellsSkinAnimalsCell DifferentiationKeratinocytesMiceMice, Inbred C57BLSignal TransductionTransforming Growth Factor betaAntigensTransforming Growth Factor betacd8epidermisimmunologyinflammationmouseresident memory T cellsskintgfb

Identifiers

PMID41468295
PMCPMC12753104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.