ArticleCell genomics2026
Evolution of protein domains and protein domain combinations provides insights into the origin and diversification of land plants.
Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The origins of water conducting tissues as clues to bryophyte evolution.Plant physiology · 2026Article
- Phylogenomic analysis supports the deep and gradual evolution of water-conducting tissues.Plant physiology · 2026Article
- Multilevel genomic constraints shape nuclear tRNA gene organization in plants.The Plant journal : for cell and molecular biology · 2026Article
- LASP1 mediates ADAM17 upregulation in high glucose to promote fibrosis in diabetic kidneys.Diabetologia · 2026Article
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Authors and funding
13 authors.
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Abstract
Protein domains are fundamental units determining protein functions. This study identified all protein domains and domain combinations from 446 genomes across all major plant lineages. We discovered more domains and domain combinations in land plants than in algae. Many novel "core" protein domains were acquired in the early evolution of streptophytes, substantially enriching the genomic toolkit that enabled plants to shift from unicellular to multicellular organization and to adapt to terrestrial life. After conquering the land, the number of ancestral core domains kept decreasing in land plants; in contrast, an increasing number of non-core domains were acquired, which, together with enhanced activity of domain shuffling, generated various novel domain combinations and expanded protein diversity. We speculate that losing existing genetic elements (core domains) is not always detrimental, as it may have reduced evolutionary constraint upon species, paving the way for biological innovation (speciation) and adaptation to changing environments.
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