Evidence map›Paper›PMID 41469152›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Quantitative Comparison of SPECT and PET Performance for Clinical Theranostic Applications.

Isabella Salerno, Nicholas Dunn, Haley White, Wilnellys Miyazaki, Kyle Jeziorski, Delynn Silvestros, Abhinav Jha, Richard Laforest, Mercy I Akerele, M Allan Thomas and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cholangio-PET/CT with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. High Quantitative Accuracy Is Possible withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Reply to "High Quantitative Accuracy Is Possible withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isabella SalernoMedical Physics Division, Department of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Nicholas DunnDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Haley WhiteDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Wilnellys MiyazakiDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Kyle JeziorskiDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Delynn SilvestrosDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Abhinav JhaPrecision Radiotheranostics Translation Center, Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Richard LaforestDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Mercy I AkereleDivision of Nuclear Medicine, Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
M Allan ThomasProgram in Quantitative Molecular Therapeutics, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Daniel L J ThorekProgram in Quantitative Molecular Therapeutics, Washington University in St. Louis School of Medicine, St. Louis, Missouri; thorekd@wustl.edu.

Funding

Validation and dissemination of novel physical phantoms for quantitative theranostics researchR01EB031962 · NIBIB · WASHINGTON UNIVERSITY · PI JHA, ABHINAV K · 2022 to 2025
$2.4M
The Radium-223 Combination Therapy Space; Improving Response and Clarifying ToxicitiesR01CA240711 · NCI · WASHINGTON UNIVERSITY · PI MICHALSKI, JEFF M., THOREK, DANIEL LYNDON JAFFE · 2020 to 2024
$2.2M
Opening the Therapeutic Window for PSMA-Targeted Molecular RadiotherapyR01CA229893 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2019 to 2024
$1.9M
NCI NIH HHS R01 CA229893NCI NIH HHS R01 CA240711NIBIB NIH HHS R01 EB031962
6 · The paper itself

Abstract

Radiopharmaceutical therapy is an emerging approach to treat metastatic disease, with the potential to enable personalized care through imaging. With the growing interest in quantitative imaging, there remains a need for systematic assessment of imageable radionuclides and scanner performance under comparable conditions. This motivated us to quantitatively and qualitatively compare SPECT and PET performance using standardized evaluation procedures to assess their effectiveness in imaging applications for targeted radiotherapy.

Indexed as

NeoplasmsPositron-Emission TomographyPrecision MedicineRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonHumansMolecular Targeted TherapyPhantoms, ImagingRadioisotopesSensitivity and SpecificityRadioisotopesRadiopharmaceuticalsimage performancePETquantitative imagingSPECTtheranostics

Identifiers

PMID41469152
PMCPMC12955544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.