Evidence map›Paper›PMID 41469479›Full record

ArticleScientific reports2025

The metabolomic profile of psoriatic arthritis patients unveils the unbalance of disease-related molecules and pathways.

M M Angioni, C Piras, V P Leoni, A Floris, M Spada, K Lilliu, M Congia, E Chessa, M Piga, L Atzori and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M M AngioniRheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.
C PirasClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy. cristina.piras@unica.it.
V P LeoniClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
A FlorisRheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.
M SpadaClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
K LilliuClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
M CongiaRheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.
E ChessaRheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.
M PigaRheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.
L Atzori *Clinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
A Cauli *Rheumatology Unit, Department of Medical Sciences and Public Health, AOU and University of Cagliari, Monserrato, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the unmet needs in psoriatic arthritis (PsA), the precise mechanisms underlying the contribution of genetic susceptibility, environmental triggers and systemic inflammation are still under investigation. As a complex and multi-factorial condition, metabolomics in PsA may offer additional insight into pathways driving the pathogenesis, allowing for a better understanding of the disease-related variations downstream of the genome and proteome. In this study, the serum metabolomics profile of PsA was compared with healthy controls, by nuclear magnetic resonance spectroscopy (

Indexed as

Arthritis, PsoriaticMetabolomeMetabolomicsAdultBiomarkersCase-Control StudiesFemaleHumansMaleMetabolic Networks and PathwaysMiddle AgedBiomarkersBCCADAPSADiabetesDisease activityGlucoseMetabolic syndromeMetabolomicsPathogenesisPsoriatic arthritis

Identifiers

PMID41469479
PMCPMC12855187

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.