ArticleNPJ vaccines2025
Identification and efficacy assessment of novel immunoprotective antigens from Mycoplasma synoviae for vaccine development.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
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Authors and funding
11 authors.
Funding
Abstract
Mycoplasma synoviae (MS) is a significant pathogen mentioned by the World Organisation for Animal Health (WOAH) and has caused substantial economic losses to the global poultry industry. The prevention and control strategies are primarily based on flock purification, antibiotic treatment, and vaccination. Given the high cost and extended timeline of flock purification, along with the growing antibiotic resistance, vaccination remains the most effective strategy for preventing MS transmission. This study employed pangenome analysis combined with reverse vaccinology (RV) to identify protective antigens against MS. At last, three proteins namely VY320 (elongation factor P), VY430 (50S ribosomal protein L6), and VY930 (YbhB/YbcL family Raf kinase inhibitor-like protein), were selected to assess their potential as candidate subunit vaccines. Furthermore, a lesion scoring method using a foot pad challenge model was established to evaluate the protective efficacy of the MS vaccine. The results indicated that the VY930 protein is an effective antigen and can activate strong humoral and cellular immunity responses in immunized flocks, superior to the inactivated vaccine. The screening strategy, evaluation methods, and related findings of this study may provide valuable insights into the prevention and control of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.