Evidence map›Paper›PMID 41469549›Full record

ArticleBMC plant biology2025

Comparative transcriptome analysis revealed that tomato response to salt stress induced by exogenous GABA and functional verification of SlGAD1.

Xiaolei Wu, Ding Yuan, Lida Chen, Yukun Sun, Yening Wang, Shiqing Jiang, Xule Sun, Xinyue Zhang, Jingrui Li, Hongbo Gao

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaolei WuKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Ding YuanKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Lida ChenKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Yukun SunKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Yening WangKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Shiqing JiangKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Xule SunKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Xinyue ZhangKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Jingrui LiKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China.
Hongbo GaoKey Laboratory of North China Water-saving Irrigation Engineering, College of Horticulture, Hebei Agricultural University, Baoding, 071000, China. hongbogao@hebau.edu.cn.

Funding

Hebei Facility vegetables Innovation Team of Modern Agro-industry Technology HBCT2023100211Natural Science Foundation of Hebei Province C2023204091S&T Program of Baoding 2494N014
6 · The paper itself

Abstract

backgroundGamma-aminobutyric acid (GABA) can act as a signalling molecule and metabolite to increase plant salt tolerance. However, it is currently unclear which genes play a major role in the defence system under the sustained effects of salt stress and how different metabolic pathways work synergistically to regulate them. The transcriptomic data and metabolite analysis of 33 leaf samples from tomato (Solanum lycopersicum L.) seedlings under 175 mmol·L− 1 salt stress revealed that the GABA + Na (GN) group presented strong salt tolerance.

resultsAmino acid synthesis, especially that of GABA, and some transporter-related genes played important roles in the GN group. Phenylalanine accumulation subsequently induced flavonoid biosynthesis via upregulating key genes involved in the flavonoid biosynthetic pathway, including the gene encoding enzyme protein PAL, 4CL, C4H, CHS and CHI. The molecular mechanism by which exogenous GABA enhances salt tolerance involves the induction of gene expression in pathways such as amino acid synthesis and transport and phenylpropanoid and flavonoid biosynthesis, increasing the content of intracellular small molecules with osmotic regulation function, thereby regulating ion transporter genes to accelerate Na+ transfer and maintain relatively stable osmotic pressure. SlGAD1 overexpression alleviated salt stress by increasing the GABA content and the flavonoid biosynthesis pathway.

conclusionsThese findings provide direct evidence that exogenous GABA affects the phenylpropanoid and flavonoid pathways and ion transporters, which will be helpful for the development of GABA as an agent for inducing salt tolerance.

Indexed as

gamma-Aminobutyric AcidPlant ProteinsSalt StressSolanum lycopersicumGene Expression ProfilingGene Expression Regulation, PlantSalt ToleranceTranscriptomegamma-Aminobutyric AcidPlant ProteinsGABANaCl stressSlGAD1Solanum lycopersicum L.Transcriptome

Identifiers

PMID41469549
PMCPMC12756926

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.