ArticleLipids in health and disease2025
Association of 'weekend warrior' and other physical activity patterns with mortality in adults with metabolic dysfunction-associated steatotic liver disease: prospective national cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRapid life rhythms have seen an increased participation in the weekend warrior pattern, but its impact on mortality risk in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This investigation aims to explore the link between physical activity (PA) patterns, along with leisure-time and occupational physical activity (LTPA/OPA), as well as mortality in adults with MASLD.
methodsThis prospective cohort study employed data sourced from National Health and Nutrition Examination Survey (NHANES), and mortality data were collected through December 31, 2019. PA was self-reported and divided into four classifications: inactive, insufficiently active, weekend warrior, along with regularly active.
resultsAmong 13,831 MASLD participants [mean (SD) age, 51.09 (16.63) years; 48.82% male], 1,191 deaths occurred in a median follow-up spanning 6.42 years. Compared to inactive participants, HR (95% CI) for all-cause mortality associated with LTPA and OPA were 0.66 (0.44 to 0.99) and 0.50 (0.30 to 0.84) in the weekend warriors, 0.63 (0.50 to 0.79) and 0.56 (0.43 to 0.72) in the insufficiently active, and 0.55 (0.43 to 0.71) and 0.62 (0.49 to 0.79) in the regularly active. Joint analyses revealed that LTPA and OPA had synergistic advantages in reducing the hazard of all-cause mortality with inactive group as the reference.
conclusionsAdults engaging in active PA patterns - whether classified as insufficient, weekend warriors, or regularly active - exhibited lower all-cause mortality rates compared to inactive participants with MASLD. For those who can't adhere to daily exercise regimens, adopting a "weekend warrior" approach provides a practical and feasible strategy to curb the progression of MASLD and reduce the risk of premature mortality linked to it. Furthermore, public health guidelines should integrate both LTPA and OPA to achieve sustainable improvements in health outcomes across the population.
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