Evidence map›Paper›PMID 41469798›Full record

ArticleCommunications biology2025

SARS-CoV-2 nsp14 induces the m

Xiaoxiao Li, Weiyi Huang, Shuhang Zhang, Wenhao Wang, Jiejing Lin, Zhuohua Wang, Qiang Zeng, Fushi Zhang, Manqi Cao, Yinan Chen and 13 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Xiaoxiao Li *The Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Weiyi Huang *The Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Shuhang ZhangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Wenhao WangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.ORCID http://orcid.org/0000-0001-9777-2143
Jiejing LinThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Zhuohua WangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Qiang ZengThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Fushi ZhangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Manqi CaoThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Yinan ChenThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Ziliang PengThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Qingrong SunThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Zhijuan LiangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Jiaxin ZhuangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Haibin YangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Panpan HouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-0453-8671
Bo ZhaoThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.ORCID http://orcid.org/0000-0002-2163-6484
Yaoqing ChenSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.ORCID http://orcid.org/0000-0002-4659-1550
Liu CaoThe Center for Infection and Immunity Study, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Zhonghan YangThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Deyin GuoThe Division of Basic Research, Guangzhou National Laboratory, Bio-island, Guangzhou, China.ORCID http://orcid.org/0000-0002-8297-0814
Ji-An PanThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China. panjan@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-2842-4126
Xiaoxue PengThe Molecular Cancer Research Center, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, China. pengxx9@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-8687-9711

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32370159National Natural Science Foundation of China (National Science Foundation of China) 82341057
6 · The paper itself

Abstract

Viruses hijack the host translation machinery to facilitate their replication by disturbing the host translation. SARS-CoV-2 nsp14 is known to inhibit host translation, yet the mechanistic details are still obscure. In this study, we report that nsp14 can elevate stress granules (SG) formation in a N7-methyltransferase activity-dependent manner. ER/Golgi localized nsp14 promotes m

Indexed as

COVID-19RNASARS-CoV-2Stress GranulesViral Nonstructural ProteinsViral Regulatory and Accessory ProteinsExoribonucleasesHost-Pathogen InteractionsHumansMethylationMethyltransferasesVirus ReplicationExoribonucleasesMethyltransferasesNSP14 protein, SARS-CoV-2RNAViral Nonstructural ProteinsViral Regulatory and Accessory Proteins

Identifiers

PMID41469798
PMCPMC12881395

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.