Evidence map›Paper›PMID 41470845›Full record

Trial reportNutrients2025

The Effect of Routine High-Soy-Protein Soymilk Intake on the Skeletal Muscle Index (SMI) in Japanese Pre-Frail Elderly Individuals with an Ordinary Life: A Post Hoc Analysis of a Randomized Controlled Trial.

Daigo Sakamoto, Yuji Terashima, Makoto Sugawara, Ryoichi Unno, Tomoyuki Watanabe, Tomoko Uno, Mitsuo Maruyama

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daigo SakamotoResearch and Development Division, MARUSAN-AI Co., Ltd., Okazaki 444-2193, Aichi, Japan.
Yuji TerashimaResearch and Development Division, MARUSAN-AI Co., Ltd., Okazaki 444-2193, Aichi, Japan.
Makoto SugawaraResearch and Development Division, MARUSAN-AI Co., Ltd., Okazaki 444-2193, Aichi, Japan.
Ryoichi UnnoResearch and Development Division, MARUSAN-AI Co., Ltd., Okazaki 444-2193, Aichi, Japan.
Tomoyuki WatanabeDepartment of Health and Nutritional Sciences, Faculty of Health Sciences, Aichi Gakuin University, Nisshin 470-0131, Aichi, Japan.ORCID 0000-0002-2627-8102
Tomoko UnoDepartment of Health and Nutritional Sciences, Faculty of Health Sciences, Aichi Gakuin University, Nisshin 470-0131, Aichi, Japan.
Mitsuo MaruyamaGeroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.

Funding

MARUSAN-AI Co., LTD. I have not received a number for this grant
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe primary outcome of a 12-week randomized controlled trial studying the effects of continuous high-soy-protein (HSP) soymilk consumption in Japanese frail and pre-frail elderly individuals has previously been reported. The authors of this post hoc study aimed to conduct a statistical analysis focusing on changes in the skeletal muscle index (SMI) and evaluate the effect of HSP soymilk intake on appendicular skeletal muscle mass (ASM).

methodsA full analysis of all subjects (

resultsIn the overall analysis (primary combined cohort), the SMI showed no significant change between the HSP and control soymilk groups (

conclusionsIn this study, no significant improvement in the SMI was observed across all subjects (frail and pre-frail elderly individuals); however, an exploratory subgroup analysis suggested that continued daily HSP soymilk intake was associated with potential benefits in pre-frail elderly individuals with high physical activity and energy intake levels. These findings are preliminary and require further research.

Indexed as

Muscle, SkeletalSoybean ProteinsSoy MilkAgedAged, 80 and overEast Asian PeopleEnergy IntakeEnergy MetabolismFemaleFrail ElderlyFrailtyHumansJapanMaleSarcopeniaSoybean Proteinsappendicular skeletal muscle massfrailtynutritional interventionskeletal muscle indexsoymilksoy protein

Identifiers

PMID41470845
PMCPMC12735966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.