Evidence map›Paper›PMID 41470907›Full record

ReviewNutrients2025

S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review.

Akira Sekikawa, Ashley Weaver, Kelly Mroz, Nina Z Heilmann, Diana A Madrid Fuentes, Kristen J Koltun, Lauren J Carlson, Kristin L Cattell, Mengyi Li, Jiatong Li and 4 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Akira SekikawaDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7197-6321
Ashley WeaverDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-4383-0106
Kelly MrozNeuromuscular Research Laboratory, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Nina Z HeilmannDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0003-3195-7713
Diana A Madrid FuentesDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-6465-3153
Kristen J KoltunNeuromuscular Research Laboratory, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0003-3234-3190
Lauren J CarlsonDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0009-0005-9421-2120
Kristin L CattellDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Mengyi LiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6514-1793
Jiatong LiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3778-5633
Timothy M HughesDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Elsa StrotmeyerDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Bradley NindlNeuromuscular Research Laboratory, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Jane A CauleyDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-0752-4408

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Arterial Stiffness, Cognition, and Equol (ACE)R01AG074971 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2022 to 2026
$12.7M
COPD SUBTYPES AND EARLY PREDICTION USING INTEGRATIVE PROBABILISTIC GRAPHICAL MODELS R01HL157879R01HL157879 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, SCIURBA, FRANK · 2021 to 2024
$2.9M
Integrative Model of Metabolomics, Equol and Atherosclerotic cardiovascular disease (IMMEA)R01HL169332 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANAGIOTIS V BENOS, AKIRA SEKIKAWA · 2024 to 2026
$2.0M
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)R01AG068629 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, HUGHES, TIMOTHY M. · 2024 to 2025
$1.5M
EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD ProgressionR01HL178032 · NHLBI · UNIVERSITY OF FLORIDA · PI PANAGIOTIS V BENOS, DAWN L DEMEO · 2025 to 2026
$1.5M
INTEGRATIVE GRAPHICAL MODELS FOR LARGE MULTI-MODAL BIOMEDICAL DATAR01LM012087 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, GLYMOUR, CLARK · 2015 to 2018
$1.3M
NHLBI NIH HHS R01 HL157879NHLBI NIH HHS R01 HL169332NHLBI NIH HHS R01 HL178032NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG068629NIA NIH HHS R01 AG074971NIH HHS 1S10AG030295-01A1NIH HHS 5UM1TR004929-02NLM NIH HHS R01 LM012087
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingBone and BonesEquolEstrogen Receptor betaOsteoporosisPhytoestrogensAgedAnimalsBone DensityFemaleGastrointestinal MicrobiomeHumansIsoflavonesMaleEquolEstrogen Receptor betaIsoflavonesPhytoestrogensbone healthestrogen receptor βgut microbiomeprecision nutritionS-equolsoy isoflavones

Identifiers

PMID41470907
PMCPMC12735577

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.