ReviewPolymers2025
Functionalization Strategies of Non-Isocyanate Polyurethanes (NIPUs): A Systematic Review of Mechanical and Biological Advances.
Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Conventional polyurethane (PU) synthesis is associated with environmental and health concerns due to the use of toxic isocyanates. In recent years, the development of non-isocyanate polyurethanes (NIPUs) has emerged as a sustainable alternative to conventional polyurethanes. However, these materials still exhibit inconsistencies in their physicomechanical and biological properties. This systematic review was conducted following the PRISMA methodology. A total of sixteen studies published between 2015 and 2025 were analyzed, focusing on functionalization techniques developed for non-isocyanate polyurethanes to evaluate their influence on physicomechanical and biological performance. The results reveal that functionalization can be achieved through the incorporation of inorganic additives, polar or ionic groups, and polymeric modifiers. Among the analyzed systems, those functionalized with azetidinium and Polyethylene glycol diacrylate (PEGDA) exhibited the most balanced performance, combining high mechanical strength, low cytotoxicity, and effective antibacterial activity. Overall, these functionalizations have demonstrated significant improvements in tensile strength, thermal stability, hydrophilicity, and antimicrobial activity, facilitating broader industrial and biomedical applications. Consequently, this review concludes that functionalization plays a pivotal role in improving the overall performance of non-isocyanate polyurethanes. It represents an effective and sustainable strategy to enhance the physicomechanical and biological behavior of these materials, supporting their development for advanced applications such as bioactive coatings, membranes, and wound dressings.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.