ReviewPharmaceutics2025
Microneedle Mediated Gas Delivery for Rapid Separation, Enhanced Drug Penetration, and Combined Therapy.
Ziyang Zheng, Ting Zhou, Hongluo Li, Jade Jillian Xian Lan Zeng, Yanping Fu, Chao Lu, Tingting Peng, Chuanbin Wu, Guilan Quan
Abstract readReview
In one paragraphReview in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Ziyang ZhengState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.ORCID 0009-0005-7092-1133 Ting ZhouState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Hongluo LiSchool of Automobile and Transportation Engineering, Guangdong Polytechnic Normal University, Guangzhou 510665, China.
Jade Jillian Xian Lan ZengInternational School, Jinan University, Guangzhou 511436, China.
Yanping FuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Chao LuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.ORCID 0000-0002-2118-8888 Tingting PengState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.ORCID 0000-0002-9685-9762 Chuanbin WuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Guilan QuanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Funding
National Natural Science Foundation of China No. 82173747, ChinaScience and Technology Projects in Guangzhou No. 202102070001, ChinaThe Keynote Project of National Natural Science Foundation of China No. 82330112, ChinaThe Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province No. 2021TQ060944, China
6 · The paper itselfAbstract
In recent years, microneedles (MNs) have emerged as a novel transdermal drug delivery technology, offering advantages such as avoidance of the first-pass effect, pain-free and minimally invasive administration, and convenient application. However, conventional MNs still face challenges, including slow detachment of MN tips from the base substrate and limited transdermal efficiency. This review systematically summarizes recent advances in MNs-mediated gas delivery for rapid separation, enhanced drug penetration, and combined therapy. The discussion encompasses the benefits and limitations of MNs and recent developments in MN-facilitated gas delivery to accelerate separation rate and improve delivery efficiency. By analyzing the therapeutic roles of various gases (e.g., H
Indexed as
combined therapydrug penetrationgas therapymicroneedlesrapid separation
Identifiers
PMID41471091
PMCPMC12736974
What Socratic holds
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