ReviewMolecules (Basel, Switzerland)2025
Phlorotannins from Phaeophyceae: Structural Diversity, Multi-Target Bioactivity, Pharmacokinetic Barriers, and Nanodelivery System Innovation.
Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Brown Macroalgal Polyphenols and Oxidative Stress: A Systematic Review and Meta-Analysis of In Vivo Evidence in Vertebrate Models.Antioxidants (Basel, Switzerland) · 2026Review
- Review
- Review
- Brown Seaweeds and Their Bioactive Compounds in Type 2 Diabetes: Mechanisms Underlying Metabolic Regulation.International journal of molecular sciences · 2026Review
- Phlorotannins and glycolipid metabolism: comprehensive regulatory roles mediated by the gut microbiota.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Phlorotannins, a unique group of polyphenolic compounds derived exclusively from brown macroalgae (Phaeophyceae), have gained substantial scientific and industrial interest due to their structural diversity and multifaceted bioactivities. These marine metabolites, composed of phloroglucinol units linked through various C-C and C-O-C bonds, exhibit broad-spectrum antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anticancer, and neuroprotective effects. Despite their promising in vitro efficacy, large-scale application remains hindered by three critical translational barriers: (i) extreme natural variability in phlorotannin content driven by ecological and seasonal factors, complicating raw material standardization; (ii) physicochemical instability and poor aqueous solubility resulting in limited oral bioavailability; and (iii) insufficient development of advanced delivery systems to ensure controlled release and targeted bioactivity. This comprehensive review integrates ecological, biochemical, and technological perspectives to establish a unified framework for translating phlorotannin research toward clinical and commercial realization. It systematically examines biosynthetic regulation, structural classification, extraction and purification methods, bioactivity mechanisms, pharmacokinetic barriers, and toxicological safety considerations. The review concludes by highlighting future research priorities essential for achieving industrial scalability, formulation reproducibility, and regulatory acceptance in marine bioactive development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.