Hydrolyzed Milk-Derived Peptides Promote Erythropoietin Pathways and Hematologic Recovery: A Cross-Species Analysis.

Liqing Zang, Akira Yokota, Misa Nakai, Kazutake Fukada, Norihiro Nishimura, Yasuhito Shimada

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liqing ZangGraduate School of Regional Innovation Studies, Mie University, Tsu 514-8507, Japan.ORCID 0000-0001-6936-795X

Akira YokotaDepartment of Integrative Pharmacology, Mie University Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.

Misa NakaiGraduate School of Regional Innovation Studies, Mie University, Tsu 514-8507, Japan.

Kazutake FukadaMie University Zebrafish Research Center, Tsu 514-8507, Japan.

Norihiro NishimuraGraduate School of Regional Innovation Studies, Mie University, Tsu 514-8507, Japan.ORCID 0000-0001-9866-4013

Yasuhito ShimadaMie University Zebrafish Research Center, Tsu 514-8507, Japan.ORCID 0000-0002-4111-8262

Funding

Rohto Pharmaceutical Co., Ltd. No

6 · The paper itself

Abstract

Anemia, characterized by reduced hemoglobin (Hb), remains a major health concern. Although iron and erythropoietin (EPO) therapies are effective, limitations in safety and accessibility have prompted interest in nutritional alternatives. Hydrolyzed milk-derived peptides (H-MDPs) contain bioactive sequences with diverse physiological effects, yet their role in erythropoiesis remains poorly defined. This study investigated the hematopoietic actions of H-MDP using zebrafish and mouse models. Adult zebrafish underwent phlebotomy-induced anemia and received oral H-MDP for 3 weeks. Hb levels, erythrocyte morphology, and expression of erythropoiesis- and iron-metabolism genes were assessed. In healthy mice, renal

Indexed as

AnemiaErythropoietinMilkPeptidesAnimalsCytokinesDisease Models, AnimalErythropoiesisHemoglobinsHydrolysisIronMiceSignal TransductionZebrafishCytokinesErythropoietinHemoglobinsIronPeptidesbioactive peptidescross-species modelEPO-iron axiserythroid differentiationhematopoietic regulationnutraceutical

Identifiers

PMID41471763

DOI10.3390/molecules30244739

PMCPMC12736080

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.