ArticleMolecules (Basel, Switzerland)2025
Discovery and Activity Evaluation of Novel Dibenzoxazepinone Derivatives as Glycogen Phosphorylase Inhibitors.
Dongrui Liu, Zhiwei Yan, Youde Wang, Shuai Li, Yachun Guo, Tienan Wang, Jinjia Guo, Liying Zhang
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Dongrui LiuLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.
Zhiwei YanLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.
Youde WangLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.ORCID 0000-0001-6422-3543 Shuai LiLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.
Yachun GuoDepartment of Pathogen Biology, Chengde Medical University, Chengde 067000, China.
Tienan WangLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.
Jinjia GuoJingfukang Pharmaceutical Group Co., Ltd., Chengde 067000, China.
Liying ZhangLaboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical University, Chengde 067000, China.
Funding
Natural Science Foundation of Hebei Province under H2023406037.
6 · The paper itselfAbstract
Inhibition of glycogen phosphorylases (GP) has been regarded as a therapeutic strategy for blood glucose control in diabetes. In this study, a series of novel dibenzoxazepinone derivatives was synthesized. The in vitro activity screening results indicated that compound
Indexed as
Enzyme InhibitorsGlycogen PhosphorylaseAnimalsBlood GlucoseDiet, High-FatDrug DiscoveryHumansHyperglycemiaHypoglycemic AgentsMaleMiceMolecular StructureObesityStructure-Activity RelationshipBlood GlucoseEnzyme InhibitorsGlycogen PhosphorylaseHypoglycemic Agentsdiabetesdibenzoxazepinone derivativesglycogenolysisglycogen phosphorylase inhibitorshypoglycemic
Identifiers
PMID41471821
PMCPMC12735688
What Socratic holds
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LicenceCC BY
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