Evidence map›Paper›PMID 41471909›Full record

ArticleMicroorganisms2025

Shared Gut Microbial and Functional Signatures Linking Parkinson's Disease and Type 2 Diabetes Revealed by Function-Anchored Metagenomics.

Ying Cui, Shiya Wang, Wenlu Zhao, Yitong Du, Lin Wang, Bingyu Han, Mingkai Zhang, Xiaojiao Xu, Sichen Wang, Xiaolong Ma and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ying CuiDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.ORCID 0009-0007-7668-2131
Shiya WangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Wenlu ZhaoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Yitong DuDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Lin WangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Bingyu HanDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Mingkai ZhangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Xiaojiao XuDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100013, China.
Sichen WangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Xiaolong MaDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Xinran XuDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Yingying ZhaoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Shuangjiang LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0002-7585-310X
Yulin WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0002-9899-7712
Houzhen TuoDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.ORCID 0000-0003-3211-3037

Funding

National Natural Science Foundation of China 82071257, 82371254Taishan Young Scholars tsqn202306029Tongzhou District, Beijing Medical and Health Industry Development Project JX2023YJ021
6 · The paper itself

Abstract

Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM) exhibit increasing comorbidity, yet the shared contribution of gut microbiota remains unclear. To investigate parallel microbial and functional alterations underlying PD, T2DM, and PD with diabetes (PDDM), we performed fecal metagenomic sequencing in 156 PD, 41 T2DM, and 44 PD with diabetes (PDDM) patients and 83 healthy controls (HC). PD and T2DM showed highly concordant microbial shifts, with 22 genera and 91 species consistently altered across disease groups compared with HC. Functional enrichment highlighted common perturbations in taurine and hypotaurine metabolism, retinol metabolism, the hypoxia-inducible factor-1 (HIF-1) pathway, and xenobiotic degradation, implicating disrupted oxidative stress responses, neuro-metabolic regulation, and detoxification. Key taxa, including

Indexed as

comorbidity mechanismsgut microbiotametabolic pathwaysParkinson diseaseshotgun metagenomicstype 2 diabetes mellitus

Identifiers

PMID41471909
PMCPMC12735499

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.