ArticleMicroorganisms2025
Alterations in Gut Microbial Co-Abundance Networks in Metabolic Syndrome: A Population-Based Cross-Sectional Study.
Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting.Microorganisms · 2026Review
- Gut microbiome dynamics and cardiometabolic disease progression: evidence from a secondary data analysis of pooled clinical datasets.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular diseases and type 2 diabetes. Gut microbiota dysbiosis has been implicated in the pathogenesis of MetS, but the mechanisms remain poorly understood. This study investigates gut microbiota interaction networks in MetS and explores their potential role in host metabolic regulation. In this population-based cross-sectional study, 221 MetS patients and 382 healthy controls were analyzed. Co-abundance network analysis was used to examine microbial interactions across the study. Significant differences in microbial co-abundance patterns were observed between MetS and healthy participants. In MetS, the gut microbiota displayed fewer and generally weaker co-abundance correlations compared with healthy controls. These changes appear to be more strongly associated with the synergistic effects of microbial interactions than solely with the abundance of individual taxa investigated here. Specific microbiota combinations were found to influence key metabolic functions, contributing to MetS development. The findings suggest that microbial interactions, rather than the abundance of individual bacteria, are associated with MetS. This study provides new insights into the role of disrupted gut microbiota networks in MetS pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.