Evidence map›Paper›PMID 41471995›Full record

ArticleMicroorganisms2025

Non-Dominant Genotypes (GII, GIV and GV) of Japanese Encephalitis Virus Exhibit an Elevated Evolutionary Rate in Nature.

Zhijie Wang, Limin Zhen, Kaiyue Wei, Baoqiu Cui, Zeyu Wang, Anum Farid, Xinyue Xia, Xiaofeng Sun, Hong Liu, Guodong Liang

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhijie WangCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Limin ZhenCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Kaiyue WeiCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Baoqiu CuiCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Zeyu WangCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Anum FaridCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Xinyue XiaCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Xiaofeng SunCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.
Hong LiuCenter for Organoid and Genome Research, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.ORCID 0000-0002-5182-4750
Guodong LiangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Funding

National Natural Science Foundation of China 81290342, 81301479, 82202593Natural Science Foundation of Shandong Province ZR2022MH115Shandong Province Key Research and Development Plan (Major Scientific and Technological Innovation Project) under the project titled "Key Technologies and Equipment Development and the Industrialization Application of Dairy Products Processing" 2023CXGC010711
6 · The paper itself

Abstract

Numerous studies have demonstrated that the Japanese encephalitis virus (JEV) is classified into five genotypes. Historically, JEV GIII and GI were the dominant strains before and after the 1990s, respectively. Recently, the non-dominant genotypes have been implicated in numerous JE outbreaks, posing significant public health challenges. This study conducted a comprehensive phylogenetic analysis of 126 JEVs covering five genotypes from 1938 to 2025 globally. Notably, it is the first study to conduct a time to most recent common ancestor (tMRCA) analysis of JEV GII. The findings indicate the common ancestor of JEV emerged approximately 1081 years ago, followed by the sequential evolution of GV, GIII, GI, GII, and GIV, which are estimated to have originated approximately 237, 184, 138, 130, and 113 years ago, respectively. The overall evolutionary rate of JEV was 3.3 × 10

Indexed as

Japanese encephalitisJapanese encephalitis virusphylogenetic analyses

Identifiers

PMID41471995
PMCPMC12735678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.