Evidence map›Paper›PMID 41472070›Full record

ArticleMicroorganisms2025

Generation of a Human-Mouse Chimeric Anti-Japanese Encephalitis Virus and Zika Virus Monoclonal Antibody Using CDR Grafting.

Yusha Liu, Jiayi Zhang, Jiayang Zhu, Hongxia Ni, Dong Chen, Meiqing Zhang, Yuqian Fang, Cheng Ma, Shuangwei Wang, Jie Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yusha LiuSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Jiayi ZhangWenzhou Seventh People's Hospital, Wenzhou 325005, China.
Jiayang ZhuSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Hongxia NiNingbo Key Laboratory of Virus Research, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China.
Dong ChenWenzhou Seventh People's Hospital, Wenzhou 325005, China.
Meiqing ZhangSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Yuqian FangSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Cheng MaSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Shuangwei WangSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Jie ChenSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Yitian ZhengSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Li ChiSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Lin CaiSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.
Jinsheng WenSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.

Funding

National Natural Science Foundation of China 31870159National Natural Science Foundation of China 32070162Natural Science Foundation of Zhejiang Province LY22C010004Ningbo Key Laboratory of Virus Research 20221CXJD030031Ningbo University Institute of Biomedical Innovation & Zhejiang Tian Yuan Biotechnology Co., Ltd SWYY2025-9One health Interdisciplinary Research Project of Ningbo University HY202403Open Project Fund of Key Laboratory of Biosafety Defense, Ministry of Education KLBD-2024-002
6 · The paper itself

Abstract

Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) is a dominant arthropod-borne disease in Asian countries. However, effective antiviral treatment for JEV has not yet been established. 2H4 is a previously identified mouse monoclonal antibody (mAb) which exhibited neutralizing activity against JEV infection. Herein, we designed a novel mAb F(ab')

Indexed as

CDR graftinghuman–mouse chimeric antibodyJapanese encephalitis virusmonoclonal antibodyZika virus

Identifiers

PMID41472070
PMCPMC12735863

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.