Evidence map›Paper›PMID 41472164›Full record

ArticleVeterinary sciences2025

Identification of Regulators for Antigen-Specific CD8

Fanghong Zhang, Siqi Niu, Alegria Agostinho Francisco, Beneque Alberto Anzol, Min Yao, Guopin Liu, Jianwu Wang, Tinghua Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fanghong ZhangCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Siqi NiuCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Alegria Agostinho FranciscoAngola Ministry of Agriculture Animal Husbandry and Veterinary Research Institute, Luanda 1000, Angola.
Beneque Alberto AnzolAngola Ministry of Agriculture Animal Husbandry and Veterinary Research Institute, Luanda 1000, Angola.
Min YaoCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Guopin LiuCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.
Jianwu WangCollege of Agriculture, Yangtze University, Jingzhou 434025, China.
Tinghua HuangCollege of Animal Science and Technology, Yangtze University, Jingzhou 434025, China.

Funding

College Students' Innovation and Entrepreneurship Training Program of Yangtze University YZ2023069National Natural Science Foundation of China 31902231Science and Technology Project for Regional Innovation of Hubei Province 2024EHA010
6 · The paper itself

Abstract

backgroundIndividual differences in immune responses to African swine fever virus (ASFV), whether induced by vaccination or natural infection, may be linked to genetic variation in the genes involved in antigen presentation.

methodsA total of nine pigs from the 112-population were selected for RNA-seq analysis. To pinpoint key transcription factors (TFs) regulating gene expression in the lymph nodes, weighted Kendall's Tau rank correlation analysis was performed to link the TF binding potential with the extent of differential expression of target genes.

resultsCD8

conclusionThese mutations may disrupt TFs binding to the ELK4 promoter, potentially reducing ELK4 expression and impairing antigen processing and presentation.

Indexed as

African swine fever virusantigen-specific CD8+ cell abundancetranscription factorsweighted Kendall’s Tau rank correlation

Identifiers

PMID41472164
PMCPMC12737470

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.