Evidence map›Paper›PMID 41472222›Full record

Observational studyViruses2025

Fatigue Severity, Cognitive Strain, and Psychological Health in Long COVID: Untangling the Interconnected Aftermath from a Dedicated Long COVID Clinic.

Ashish Bhargava, Hemang Patel, Susan Szpunar, Mamta Sharma, Michael Somero, Shyam Moudgil, Louis Saravolatz

Abstract readObservational Study
In one paragraph

Observational study in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashish BhargavaDivision of Infectious Disease, Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA.ORCID 0000-0001-6326-0908
Hemang PatelDivision of Infectious Disease, Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-0916-3271
Susan SzpunarThomas Mackey Center for Infectious Disease Research, Henry Ford St. John Hospital, 19251 Mack Avenue, Suite 575, Grosse Pointe Woods, Detroit, MI 48236, USA.
Mamta SharmaDivision of Infectious Disease, Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA.ORCID 0000-0003-1232-0485
Michael SomeroDivision of Infectious Disease, Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA.
Shyam MoudgilDivision of Neurology, Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA.
Louis SaravolatzDivision of Infectious Disease, Department of Internal Medicine, Henry Ford St. John Hospital, Detroit, MI 48236, USA.

Funding

Henry Ford Hospital Medical staff funds
6 · The paper itself

Abstract

Post-acute sequelae of SARS-CoV-2 infection (PASC) frequently includes persistent fatigue and cognitive dysfunction, but the relationship between these symptoms remains poorly defined. In this prospective observational study at the Henry Ford St. John Long COVID Clinic (LCC) from July 2023 to March 2025, we assessed fatigue severity using the Fatigue Assessment Scale (FAS) and examined its relationship with depression and cognitive symptoms. New patients completed demographic and clinical questionnaires, Patient Health Questionnaire (PHQ)-9, and Montreal Cognitive Assessment (MoCA) at their first LCC visit. Among 41 patients, 35 (85.4%) met the inclusion criteria for fatigue (FAS ≥ 22), with 18 (51.5%) experiencing severe fatigue (FAS > 34). Severe fatigue was significantly associated with shortness of breath, chest pain, and depression. Patients experiencing severe fatigue had significantly higher median PHQ-9 scores (12.5) compared to those with mild to moderate fatigue (5.0,

Indexed as

Cognitive DysfunctionFatigueMental HealthPost-Acute COVID-19 SyndromeAdultAgedDepressionFemaleHumansMaleMiddle AgedProspective StudiesSARS-CoV-2Severity of Illness IndexSurveys and Questionnairescognitive impairmentdepressionfatiguelong COVIDneuropsychiatric symptomsPASCpsychological health

Identifiers

PMID41472222
PMCPMC12737736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.