Evidence map›Paper›PMID 41472306›Full record

ArticleViruses2025

Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway.

Yuxin Yang, Xinmiao Li, Haitao Shi, Jiaying Yu, Chen Gao, Yuanhong Liu, Wenjun Feng, Luyuan Peng, Bendong Fu, Pengfei Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxin YangCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Xinmiao LiCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Haitao ShiCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Jiaying YuCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Chen GaoCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Yuanhong LiuCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Wenjun FengCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Luyuan PengCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Bendong FuCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.
Pengfei YiCollege of Veterinary Medicine, Jilin University, Changchun 130062, China.ORCID 0000-0002-6898-7388

Funding

the National Key R&D Program of China 2023YFD1800804-05
6 · The paper itself

Abstract

Porcine Reproductive and Respiratory Syndrome (PRRS), caused by the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), is a highly contagious viral disease responsible for significant economic losses in the global swine industry. Quercetin, a polyphenolic flavonoid known for its antiviral properties, was investigated in this study for its ability to inhibit PRRSV replication by modulating autophagy. Our study demonstrates that quercetin can inhibit PRRSV replication in MARC-45 cells by regulating the degradation of autophagosomes and suppressing the generation of autophagosome. We further suggest that quercetin inhibits PRRSV-induced autophagy via the PI3K/Akt/mTOR signaling pathway, suppressing autophagosome formation while promoting autophagosome-lysosome fusion, ultimately leading to reduced PRRSV replication. In conclusion, our study demonstrates that quercetin inhibits PRRSV replication by regulating autophagy through the PI3K/Akt/mTOR pathway.

Indexed as

Antiviral AgentsAutophagyPorcine respiratory and reproductive syndrome virusProto-Oncogene Proteins c-aktQuercetinSignal TransductionTOR Serine-Threonine KinasesVirus ReplicationAnimalsAutophagosomesCell LinePhosphatidylinositol 3-KinasesPorcine Reproductive and Respiratory SyndromeSwineAntiviral AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuercetinTOR Serine-Threonine KinasesautophagyPRRSVquercetin

Identifiers

PMID41472306
PMCPMC12737713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.