ArticleFrontiers in reproductive health2025
Anoscrotal distance and urogenital anomalies in ART-conceived male infants: a retrospective cohort study.
Article in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Assisted reproductive technology (ART) is widely used, yet potential effects on androgen-sensitive male genital development remain a concern. Anoscrotal distance (ASD), a validated marker of prenatal androgen exposure, may differ in ART-conceived infants. This study compared ASD and urogenital anomalies among male newborns conceived via frozen-thawed embryo transfer (FET) using natural-cycle (tNC) or hormone-replacement therapy (HRT) protocols versus natural conception (NC). Methods: In this retrospective cohort of 432 singleton male births (156 NC, 132 FET-tNC, 144 FET-HRT) delivered between 2021 and 2023, neonatal outcomes, including ASD, hypospadias, and undescended testes (UDT), were assessed. Group comparisons were performed using standard statistical tests, and exploratory modelling was conducted to identify variables most strongly distinguishing conception groups. Results: Median ASD was significantly longer in NC infants (26.2 mm) than in FET-tNC (24.9 mm) and FET-HRT (24.6 mm) infants ( Conclusions: Male infants conceived via FET consistently exhibited shorter neonatal ASD than naturally conceived infants, suggesting subtle alterations in androgen-sensitive genital development. These findings underscore the importance of incorporating careful genital assessment and ART-specific counseling into neonatal care.
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